Finding a way to reverse aging has been a long-term objective of scientists and researchers alike for decades now. Recently, they found that senolytics drugs have opened up a new path bringing them closer to their goals. Find out what senolytics drugs are and how they work.
In This Article:
- What Exactly Are Senolytic Drugs?
- How Do Senolytic Drugs Work?
- Targeting Senescent Cells
- The Hunt for Anti-Aging Compounds
- Other Potential Uses of Senolytic Drugs
Senolytic Drugs – a Revolutionary Approach to Anti-Aging
1. What Exactly Are Senolytic Drugs?
Senolytic drugs are chemicals that specifically trigger apoptosis in senescent cells. These cells proliferate in a range of tissues as we age, as well as in sites of sickness in several chronic illnesses. In animal research, targeting senescent cells with genetic or pharmacological approaches delays, prevents, or alleviates a wide range of age-related phenotypes, chronic diseases, geriatric syndromes, and loss of physiological resilience.
2. How Do Senolytic Drugs Work?
Proper cell regeneration is required for long life and the proper functioning of every organ, bone, and system in the human body. Healthy cells in our bodies are continually dividing, renewing, and being replaced by new cells and stem cells at different rates.
Skin cells renew every 27 days, which helps our skin recover after being wounded or scraped. And our blood cells renew, so there’s no need to worry about becoming sick from donating.
This process is slowed or halted as we grow older. Our stem and non-stem cells are both going through senescence, which is when they cease reproducing and renewing. They are known as “zombie cells” because they no longer sustain the tissues they are a part of. They also produce chemical signals that can lead other cells in the vicinity to likewise go into a senescent phase.
Normally, our immune system or a process known as apoptosis (programmed cell death) eliminates senescent cells from our bodies. As we get older, we lose the ability to fight disease because our immune systems degenerate, and senescent cells aren’t adequately removed from the body.
3. Targeting Senescent Cells
Senescent cells aren’t necessarily a bad thing. Senescence is a fundamentally defensive process that occurs when a cell understands it is too damaged to continue dividing and consequently limits its development. For example, a malignant mutation may cause a cell to become senescent and begin dividing uncontrollably, resulting in a tumor. Wound-induced damaged cells can also develop senescence.
Senescent cells have been found to assist in treating a variety of age-related illnesses in preliminary tests. This suggests that senolytic therapies may one day help us age gracefully. However, medicines that target and destroy senescent cells must be highly specific. Treatments that target all cells in the body may cause harm to healthy cells as well.
4. The Hunt for Anti-Aging Compounds
In 2011, a team from the Mayo Clinic in the United States first examined senolytics for their anti-aging potential. Since then, senolytics have attracted the interest of experts from all around the world. A study conducted in 2016 found that giving senolytics to mice increased their longevity by 17 to 35 percent.
Because of these results, many scientists are now trying to identify ways to target senescent cells to cure various age-related illnesses. Researchers at Erasmus University Medical Center in the Netherlands have discovered a peptide that destroys senescent cells without harming the surrounding healthy cells.
It was discovered that using senolytics for the treatment of Idiopathic Pulmonary Fibrosis (IPF), a chronic lung disease that causes scarring in the lungs, showed promising results in a first-in-human trial conducted by researchers at the University of Texas at San Antonio, Mayo Clinic, and Wake Forest School of Medicine, among other institutions.
There is no other medication or therapy available to increase the six-minute timed walking distance of patients who participated in this trial by an average of 21.5 meters.
5. Other Potential Uses of Senolytic Drugs
In addition to increasing your lifespan, this reverse aging drug also has many other potential benefits in treating various diseases and conditions, including:
- Heart Disease
- Heart Attacks
- Blood Vessel Disease
- Hearing Loss
- Vision Loss
- Vertebral Disk Degeneration
- Liver Steatosis
- Neurodegenerative Disorders such as Alzheimer’s and Parkinson’s Disease
- Metabolic Disorders such as Diabetes
- Pulmonary Fibrosis
With that said, if you’re interested in taking countermeasures and preventing the aging process, you can try a Senolytic supplement from Tailor Made Health. And it’s best that you start early because it will help you slow the aging process and help you prevent many other diseases caused by age.
If you have questions about senolytic drugs or any of the conditions discussed here, connect with us and learn more. Get information and support from our Blogs and shop our Supplements and Cosmeceuticals for Integrative Medicine.
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